SmartFlow Technologies has provided systems to recover target proteins from fermentation or extraction based production processes. Numerous customers have found improvements in the final quality of heat sensitive products by implementing ConSep® based filtration systems. SmartFlow systems have been able to concentrate protein solutions to higher concentrations than traditional TFF systems because of the open channel design of the ConSep® modules.
Energy savings can also be achieved by implementing SmartFlow TFF systems prior to spray drying, but delivering the product to the spray dryers at the optimum moisture level in a controlled manner.
When applied to protein concentrates, ConSep® based filtration can provide a number of benefits.
| Suspended solids removal | Dissolved solids removal |
| Select the range of protein MW concentrated | Improved product recovery |
| Improved product efficacy | Retain proteins with custom membrane pore sizes |
By selecting the right membrane to incorporate into the ConSep® modules, SmartFlow can develop customized protein recovery profiles to match your process needs.
Protein recovery operations from fermentation based process can be improved by implementing a DiaSync® integrated filtration system to simultaneously isolate the protein of interest from the starting material and concentrating it while removing small MW ions and contaminants in the concentration step. A representation of the patented DiaSync® systems is below.
